• Users Online: 48
  • Print this page
  • Email this page


 
 
Table of Contents
LETTER TO EDITOR
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 52-53

“Boomerang sign” in dengue encephalitis


1 Department of Medicine, Jawaharlal Nehru Medical College, DMIMS University, Wardha, Maharashtra, India
2 Department of Pathology, Jawaharlal Nehru Medical College, DMIMS University, Wardha, Maharashtra, India

Date of Submission30-Jan-2019
Date of Acceptance31-Jan-2019
Date of Web Publication18-Feb-2019

Correspondence Address:
Dr. Priyansh Bhayani
Department of Medicine, DMIMS University, Jawaharlal Nehru Medical College, Sawangi, Meghe, Wardha - 442 001, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/INJMS.INJMS_6_19

Rights and Permissions

How to cite this article:
Bhayani P, Acharya S, Shukla S. “Boomerang sign” in dengue encephalitis. Indian J Med Spec 2019;10:52-3

How to cite this URL:
Bhayani P, Acharya S, Shukla S. “Boomerang sign” in dengue encephalitis. Indian J Med Spec [serial online] 2019 [cited 2019 Mar 20];10:52-3. Available from: http://www.ijms.in/text.asp?2019/10/1/52/252478

Sir,

A 16-year-old female came with complaints of fever for 7 days. On the 6th day of fever, she presented with diplopia and headache. She presented to us with altered sensorium. On examination, she was febrile (100° F), pulse rate of 120 beats/min, and blood pressure 90/60 mmHg. On neurological examination, she had altered sensorium, Glasgow Coma Scale score 10/15, right lateral rectus palsy, and bilateral nystagmus, and Kernig's sign was positive. On abdominal examination, spleen was palpable 4 cm from the left costal margin. Other system examinations were normal.

Cerebrospinal fluid examination was within normal limits. Blood tests for malaria and leptospirosis were negative. Weil–Felix reaction was negative. Dengue immunoglobulin M antibody was positive.

A contrast magnetic resonance imaging of the brain revealed nonenhancing localized restricted diffusion in the splenium part of the corpus callosum on diffusion-weighted imaging, resembling “boomerang sign” [Figure 1]. The patient was managed conservatively which resulted in complete resolution of the sign in 2 weeks.
Figure 1: Diffusion-weighted imaging showing boomerang sign

Click here to view



  Discussion Top


Transient splenial hyperintensity (TSH) can be noted in multiple conditions, as mentioned in [Table 1].[1],[2] Dengue encephalitis as a cause of TSH has not been reported in literature. TSH usually presents as one of two characteristic patterns, being either a well-demarcated, oval lesion in the midline within the corpus callosum or a more diffuse, irregular lesion extending throughout the splenium and involving the adjacent hemispheres. The proposed mechanisms implicated include a temporary breakdown of the blood–brain barrier, extrapontine myelinolysis, intramyelinic edema due to inflammation leading to microvascular endothelial injury, direct viral invasion of neurons, and toxicity or hypersensitivity to antiepileptic drugs.[3] The boomerang sign may denote a nonspecific brain injury since its clinical significance is not clear yet. These signs are reversible and disappear within a few weeks. The exact reason for increased predilection of the splenium of the corpus callosum is still not known.
Table 1: Differential diagnosis for transient splenial hyperintensity

Click here to view


Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

None.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Doherty MJ, Jayadev S, Watson NF, Konchada RS, Hallam DK. Clinical implications of splenium magnetic resonance imaging signal changes. Arch Neurol 2005;62:433-7.  Back to cited text no. 1
    
2.
Malhotra HS, Garg RK, Vidhate MR, Sharma PK. Boomerang sign: Clinical significance of transient lesion in splenium of corpus callosum. Ann Indian AcadNeurol 2012;15:151-7.  Back to cited text no. 2
    
3.
Bulakbasi N, Kocaoglu M, Tayfun C, Ucoz T. Transient splenial lesion of the corpus callosum in clinically mild influenza-associated encephalitis/encephalopathy. AJNR Am J Neuroradiol 2006;27:1983-6.  Back to cited text no. 3
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Discussion
References
Article Figures
Article Tables

 Article Access Statistics
    Viewed34    
    Printed1    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal