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REVIEW ARTICLE
Year : 2019  |  Volume : 10  |  Issue : 2  |  Page : 66-71

Sources and toxicological effects of lead on human health


Department of Pharmacy, Tripura University (A Central University), Agartala, Tripura, India

Correspondence Address:
Dr. Kuntal Manna
Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Agartala - 799 022, Tripura
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/INJMS.INJMS_30_18

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Lead toxicity is one of the most hazardous metal toxicities. It can enter the body through lead-based paint, dust, water, soil, tableware, and folk medicines. Children are especially prone to develop lead toxicity. Lead acts by inducing oxidative stress due to inefficient replenishment of glutathione. Lead can also cause hemolytic anemia due to disruption of the cellular membrane by lipid peroxidation. Lead toxicity also affects neurotransmitter levels and causes severe health issues related to organ damage, some even leading to death. The main aim of this review article is to summarize lead toxicity detection, its sources, and its mechanism including various toxicological effects on human health. It also focuses on the prevention and treatment of lead toxicity.


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