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ORIGINAL ARTICLE
Year : 2019  |  Volume : 10  |  Issue : 2  |  Page : 99-104

Correlation between serum lipid fractions and radiological severity in patients with drug-resistant pulmonary tuberculosis: A cross-sectional pilot study


1 Department of General Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India
2 Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India
3 Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Correspondence Address:
Dr. Manel Arjun Nayak
Department of General Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka - 575 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/INJMS.INJMS_1_19

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Background: We aimed to determine if serum cholesterol and body mass index (BMI), which are important in maintaining immunity, have any impact on the radiological severity in patients with drug-resistant pulmonary tuberculosis (DR-TB). Materials and Methods: A cross-sectional pilot study was conducted over 2 years in adults with newly diagnosed DR-TB. The radiological severity of the disease was determined using a chest X-ray (CXR) scoring formula. Correlation between the lipid fraction levels, BMI, and the CXR scores was determined using Pearson's correlation coefficient. Results: Thirty-three patients were included in the study. A significant negative correlation was seen between the CXR severity scores and total cholesterol (r = −0.546,P = 0.001), high-density lipoprotein-cholesterol (r = −0.479,P = 0.005), low-density lipoprotein-cholesterol (r = −0.431,P = 0.012), and BMI (r = −0.352,P = 0.044). Conclusions: Low serum cholesterol levels and low BMI were associated with an increased radiological severity which, in turn, could result in increased infectivity. Adequate nutritional supplementation in the diet of patients to increase BMI, and serum cholesterol levels, could potentially decrease the severity, and also consequently, transmission, and incidence of DR-TB.


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