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Year : 2021  |  Volume : 12  |  Issue : 3  |  Page : 142-146

A study of prothrombotic factors in human immunodeficiency virus-infected patients

1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Medicine, VMMC and Safdarjung Hospital, New Delhi, India
3 Department of Hematology, VMMC and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Jitendra Mohan Khunger
Consultant Haematologist and Assoc. Professor, Department of Haematology, Vardhman Mahavir Medical College and Safdar Jang Hospital, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/INJMS.INJMS_130_20

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Introduction: Human immunodeficiency virus (HIV) infection has been described as a hypercoagulable state. Some studies suggest that thrombotic events may be 2–10 times more prevalent in this group than in the general population. Subjects and Methods: This was a single-center, cross-sectional case–control study. Thirty confirmed HIV cases of age group 20–60 years were enrolled. A similar number of age- and sex-matched healthy volunteers were taken as controls. CD4 cell count, protein C, protein S, antithrombin III (AT III), anticardiolipin antibody, and highly sensitivity C-reactive protein (hs-CRP) estimation was done and correlated with the CD4 counts. Results: Among HIV cases, 40% were protein C deficient, while 10% were deficient in control group (P = 0.015). One-third (33%) were AT III deficient in HIV-infected group, while none were observed AT III deficient in control group (P < 0.001). Protein C and antithrombin levels did not correlate with CD4 count. Protein S levels were normal in all the HIV-infected cases. Anticardiolipin antibody was not detected in any patient among HIV group. Mean hs-CRP levels in cases and controls were 20.18 ± 12 mg/dl and 3.32 ± 5.13 mg/dl, respectively (P < 0.0005). Conclusion: Protein C deficiency and AT III deficiency were found to be significantly associated with HIV infection. The hs-CRP levels were significantly elevated in HIV-infected patients' protein C deficiency, increased level of hs-CRP, and AT III deficiency did not correlate with CD4 cell count.

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