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CASE REPORT
Year : 2021  |  Volume : 12  |  Issue : 3  |  Page : 175-178

Clinical efficacy and safety of combined house dust mite subcutaneous immunotherapy and omalizumab in five cases of allergic rhinitis and asthma


1 Department of Allergy/ Asthma BLK Hospital and Director at National Allergy Center, New Delhi, India
2 National Allergy Centre, New Delhi and BLK Superspeciality Hopital, New Delhi, India

Correspondence Address:
Dr. P C Kathuria
1/3 East Patel Nagar, New Delhi - 110 008
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/injms.injms_7_21

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Allergen immunotherapy (AIT) is a well-recognized treatment for altering the natural course of respiratory allergy which builds immune tolerance and prevents progression of allergic diseases. In our five cases of house dust mite (HDM)-driven allergic rhinitis and asthma, combined HDM Subcutaneous Immunotherapy (HDM-SCIT) for 2 years with omalizumab for more than 12 months has achieved disease remission in four cases and disease control in one case along with long-term effect for 3 years after discontinuation of AIT. We hypothesize that combining HDM-SCIT and omalizumab is a promising strategy as it is effective, safe, and synergistic having immune-modifying activity in cases of HDM-driven Allergic Rhinitis and Asthma.


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